Endocrine Abstracts

Background: We would like to present a case of pancreatic encephalopathy induced by DKA induced hypertriglyceridemia. The triad of acute pancreatitis, hypertriglyceridemia and diabetes is a rare occurrence. Through our case we aim to highlight the importance of making an early diagnosis as a delay in diagnosis can worsen outcomes.Case history: We present the case of a 51 year old Type 2 Diabetic non compliant with her medications who was admitted to the ...

Introduction/Aim: The diagnosis and management of hypothyroidism in pregnancy is a domain of shifting paradigms, with changes in guidelines, which may have led clinicians to confusion or angst (Endocrine Today; October 2019). Since sentiment analysis (SA) of medical texts can be implemented (Artificial Intelligence in Medicine 2015; 64: 17–27) we sought to use SA regarding this clinical issue.Materials/Methods: We collected the English language abst...

Primary adrenal insufficiency is due to impairment of the adrenal gland with ~80% of the cases being due to autoimmune adrenalitis (Addison’s disease). Other cases of primary adrenal insufficiency might be idiopathic, caused by adrenal metastases, or due to congenital adrenal hyperplasia. Adrenal insufficiency might also be induced by infectious diseases e.g. COVID-19 and, as seen lately in an increasing number of patients, by novel medications targeting hypertension and ...

Background: Several treatment options exist after thyroid malignancy has been ruled out in patients with multinodular goiter (MG). Surgery efficiently reduces the goiter size but carries a risk of both surgical and anesthetic complications while in recent years, levothyroxine suppressive therapy has been abounded. I131 therapy is the only nonsurgical alternative; however, the effectiveness diminishes with increasing goiter size and depends on iodine sufficiency in some areas. ...

Introduction: Familial hypocalciuric hypercalcemia (FHH) causes lifelong hypercalcemia, which, in general, is not associated with significant morbidity. FHH1, the most common type of the disease, is inherited in an autosomal dominant pattern and caused by inactivating mutations in the Calcium Sensing Receptor (CaSR) gene, located in chromosome 3. Inactivation of CaSR in parathyroid cells results in a shift of calcium set point to higher values with consequent...

Introduction: Low bone density is a frequent finding in both women and men of older age. There is not enough data about bone density in younger adults and especially men. In this study we measured bone density in healthy males per decade of age.Method: We measured bone density (BMD), T-score, Z-score and body mass index (BMI) in 1902 healthy men, age 20–59 years old. The study population was divided into four groups according to th...

Background and Objective: Although several epidemiological studies have been conducted, the impact of Follicle Stimulating Hormone Receptor (FSHR) polymorphisms on male infertility remains unclear. The aim of this study was to investigate the prevalence of specific FSHR Single Nucleotide Polymorphisms (SNPs) in the Greek population and associate the latter with the clinical phenotype.Patients and Methods: We enrolled 96 subjects: men with idiopathic non-...

Introduction: Neurofibromatosis type 1 or von Recklinghausen disease is a systemic hereditary disease characterized by disorders regarding the skin, neural and skeletal systems. Osteoporosis is one of the skeletal manifestations of neurofibromatosis type 1, being associated with increased fracture risk. Neurofibromatosis type 1 is associated with a propensity for the development of cancer, breast cancer in particular being associated with neurofibromatosis type 1.<p class=...

During the establishment of pregnancy, the endometrium undergoes dynamic remodelling in order to establish a ‘receptive’ microenvironment. Decidualisation, a key part of this process, is characterised by differentiation of endometrial stromal fibroblasts which secrete factors that regulate implantation and placental development. Recent studies in our laboratory have revealed that decidualisation results in altered expression of enzymes that regulate biosynthesis and ...

Introduction: Despite more than 60 years’ experience with radioactive iodine 131I (RAI) treatment of Graves’ disease (GD) about the most appropriate dosing regime is still controversial. The objective of our research was to analyse the outcome of RAI therapy in our cohort of patients.Methods: Retrospectively, we analysed 603 patients with GD (500 women and 103 men, mean age 51.5±12.7 years) treated with RAI. According to recomme...